Curcuma longa is an important medicinal plant and a spice in Asia. Curcumin (diferuloylmethane) is a hydrophobic bioactive ingredient found in a rhizome of the C. longa. It has drawn immense attention in recent years for its variety of biological and pharmacological action. However, its low water solubility, poor bioavailability, and rapid metabolism represent major drawbacks for its successful therapeutic applications. Hence, researchers have attempted to enhance the biological and pharmacological activity of curcumin and overcome its drawbacks by efficient delivery systems, particularly nanoencapsulation. Research efforts so far and data from the available literature have shown a satisfactory potential of nanorange formulations of curcumin (Nanocurcumin), it increases all the biological and pharmacological benefits of curcumin, which was not significantly possible earlier.

Since 2011, more than 1,500 publications related to curcumin nanoparticles were available in the NCBI PubMed database. In the recent three decades, researchers have worked on curcumin for its various functional and biological features viz., anti-inflammatory, anti-oxidant, anti-mutagenic, antimicrobial activity, antitumoral, wound healing, and antiangiogenesis effects. Existing research data provide evidence to support the curcumin’s beneficial effects on different human diseases including cancer, diabetes, lung and chronic kidney diseases, neurological disorders, metabolic disease, liver problems, cardiovascular disease, digestive disorders, and other inflammatory diseases. Despite its reported benefits, multiple factors often limit the practical applications of curcumin. For instance, poor water solubility and physicochemical instability, low pharmacokinetics and bioavailability, poor bioactive absorption, rapid metabolization, low penetration and targeting efficacy, sensitivity to alkaline conditions, metal ions heat and light. However, these obstacles being solved by encapsulating curcumin into nanoformulations (nanocurcumin). Integrating curcumin into nanocarriers through various methods is an appropriate and fruitful choice to upsurge the biological activity of curcumin, which increases its bioavailability and solubility, long time circulation, and retention in the body, and overcome physiological barriers of curcumin. Also, it can reduce the unintended toxicity to surrounding normal cells/tissues by diffusing the indent tissues.

Each film-coated tablet of TurmiblissTM contains-

Nanocurcumin (30%) ........ 500 mg

Piper Nigrum (10%) ....... 5 mg

TurmiblissTM is a synergistic combination of Nano-Curcumin with Piperine for the treatment and prevention of various chronic conditions including pre-cancerous (Oral sub-mucous fibrosis, Oral Leukoplakia, Lichen Planus), Cancer, Rheumatoid arthritis and other Inflammatory conditions. 

Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione]1 is a major chemical component of the plant Curcuma longa. Curcumin possesses diverse pharmacologic effects including DNA-protecting, anti-carcinogenic, anti-inflammatory, anti-oxidant & immunomodulatory. Curcumin is USFDA approved & put in the category "Generally Regarded as Safe (GRAS)" which means that they are safe to use in daily nutrition.

Piperine [1-(5-(1,3-benzodioxol 5-yl)-1-oxo-2,4-pentadienyi] piperidine) is a standardized extract obtained from Piper nigrum, containing not less than 95% piperine. Piperine is a natural bioavailability enhancer and is proven to improve the uptake and utilization of curcumin.

1. ANTI-CARCINOGENIC

Curcumin exerts clinically relevant anti-cancer effects & opens up a new avenue for chemoprevention & treatment of Oral, Skin, Colorectal, Breast & other types of cancers. Curcumin induces apoptosis, inhibits cell cycle progression, invasion & metastasis by blocking NF-KB & other molecular factors.

2. DNA PROTECTING

Curcumin inhibits NF-KB & various other chemical mediators responsible for DNA damage & disease progression. Curcumin is also found to protect DNA by preventing the interaction of DNA with various Carcinogens.

3. IMMUNOMODULATOR

Curcumin shows potent immunomodulatory action that can modulate the activation of T cells, B cells, Macrophages, Neutrophils, Natural killer cells, and Dendritic cells. Curcumin can also downregulate the expression of various pro-inflammatory Cytokines including TNF, Interleukins and Chemokines. Interestingly, Curcumin can also enhance antibody responses.

4. ANTI-INFLAMMATORY

Research shows Curcumin is a highly pleiotropic molecule capable of interacting with numerous molecular targets involved in inflammation. Curcumin modulates the inflammatory response by down-regulating the activity of Cyclooxygenase-2 (COX-2), Lipoxygenase, and inducible Nitric Oxide Synthase (INOS) enzymes, Inhibits the production of the inflammatory Cytokines- Tumor Necrosis Factor-alpha (TNF-a), Interleukin (IL)-1, -2, -6, -8, and-12.

5. ANTI-OXIDANT

Curcumin is a potent scavenger of reactive oxygen species (ROS) including Superoxide anion, Nitric oxide & Hydroxyl radicals. In various clinical studies, it has been shown that Curcumin increases levels of vitamins C & E in saliva & prevents lipid peroxidation & DNA damage.

Curcumin is poorly absorbed so piperine has been added to enhance absorption of curcumin Piperine, a known inhibitor of Hepatic and Intestinal Glucuronidation, inhibits several enzymes responsible for the metabolism of curcumin so more curcumin enters the body in active form and remains within the target cells for longer period of time for better result. 

In humans after a dose of 2 g Curcumin alone, serum levels were either undetectable or very low. Concomitant administration of Piperine 20 mg produced much higher concentrations from 0.25 to 1 h post-drug (P<0.01 at 0.25 and 0.5 h, P < 0.001 at 1 h), the increase in bioavailability was 2000%. The study shows that in the dosages used, Piperine enhances the serum concentration, extent of absorption and bioavailability of Curcumin in humans with no adverse effects.

Nanoformulations of curcumin hold promise as a drug delivery system and overwhelmed these difficulties and increased its bioavailability. Particle size, surface area, surface charge, and hydrophobicity are important physicochemical properties that make nano-curcumin more effective than native curcumin. Previous studies demonstrated that these properties can lead to an increased rate of solubility and higher oral bioavailability, including high pharmacokinetic profile, and active targeting. Due to its size, nanocurcumin is considered an ideal choice to use as a drug compared to normal curcumin because of its larger surface area. Nanocurcumin enters organs that are almost cannot able to enter by curcumin.

• Pre-cancerous lesions-

1. Oral Sub-mucous fibrosis (OSMF)

2. Oral Leukoplakia

3. Lichen planus

• Cancers (Oral /Lung /Head & Neck /Prostate /Cervical /Colon Cancer etc.)

• Rheumatoid Arthritis /Osteoarthritis

• Cough /Cold /Bronchitis /Allergy /Sinusitis 

• Liver Problems, Fatty Liver /IBS /IBD

• Skin Diseases: Psoriasis, Eczema

• Adjuvant Therapy in Malaria

• Curcumin Protects the lungs from damage caused by Cigarette smoking and inhibits chemically Induced duodenal ulcers.

One tablet three or two times a day or as prescribed by Physician

No known contra-indication. The safety in Pregnancy & Lactation has not been established.

Warfarin and other anti-coagulants

No known side effects have been reported. In various clinical studies, Curcumin has been found to be safe at very high doses (8g/day) with no dose limiting toxicity. The USFDA has approved Curcumin as "Generally regarded as safe (GRAS)".

Curcumin is known to inhibit blood clotting; it should be avoided for a two-week period prior to major surgery and not used in conjunction with blood thinners such as Warfarin and Plavix. It is also known to aggravate gallstone problems.

Alu Alu pack of 10 tablets each in a monocarton. 10 monocarton in a box. 

Store in a cool, dark & dry place. keep out of reach of children.